Cell Biology

Discover the top 1% of cell biology preprints on bioRxiv, ranked by QED Score for originality and validity. Browse new research on cell signaling, organelle function, the cytoskeleton, cell division, and membrane trafficking, and see the claims and evidence behind each paper at a glance.

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How the QED Score works

QED Score is a validated AI-based quality metric that evaluates life science papers on two dimensions: originality and validity. Each manuscript is anonymized, broken down into its claims and supporting evidence, and examined by specialized AI agents for statistical rigor, consistency across figures, and fit with the existing literature. Scores are percentile ranks, so they're comparable across fields. In blinded tests, expert professors sided with QED Score over journal rank in 75% of decisive cases.

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Physiology

Animal Behavior and Cognition

Plant Biology

Developmental Biology

Cell Biology

Structural evolution of the MTCH family of mitochondrial insertases

Selective autophagy of whole micronuclei suppresses chromosomal instability

Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria to nucleus signaling

MitoAtlas: a Domain-Resolved Spatial Map of the Human Mitochondrial Proteome

Geometric optics organizes organelle interactions and positioning

Directional branch migration remodels the meiotic Holliday junction landscape

Subcellular transcriptome sequencing with single cell APEX-seq identifies regulators of cell-cell interactions

Shape2Fate: a morphology-aware deep learning framework for tracking endocytic and exocytic carriers at nanoscale

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

Ribosome Molecular Aging Shapes Translation Dynamics

Polyamines buffer labile iron to suppress ferroptosis

Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation

Mitochondrial control of glycerolipid synthesis by a PEP shuttle

CHPT1–LCAT rewires lipolysis towards ferroptosis

Autolamellasomes: Linking Autophagy-Dependent ER Degradation to Whorled Lysosome Biogenesis

A nano-liquid hub integrating growth and immune-evasion signaling to promote cell survival

Unwinding of RNA G-quadruplexes induces mouse and human totipotency

Single-cell profiling reveals pervasive heterogeneity in subcellular RNA localization

Microglia Rank signaling regulates GnRH function and the Hypothalamic-Pituitary-Gonadal axis

Metabolic stress reveals widespread accumulation of cap-unmethylated RNAs

Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation

Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism

RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion

A minor muscle stem cell population functions as metabolic Trojan horse fueling systemic aging by succinate induced epigenetic reprogramming

Human heart organoids reveal a regenerative strategy for mitochondrial disease

Nuclear N-Glycosylation Redefines the Glycoscape and Directs Cell Identity

Nuclear mechanostability emerges from satellite DNA condensation into chromocenters

PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration

Structural Basis of Asymmetric Class C GPCR activation and distinct Gq coupling induced by force stimulation

Interorganelle competition for linoleic acid underlies steatotic liver pathology

Organelle biogenesis on a synthetic bead

The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins

p62 protein pleomorphism confers tissue-specific function

How the TREX-2 complex associates with the nuclear pore

Intravital single-molecule imaging reveals cytoskeletal turnover as a driver of membrane remodeling in live animals

Metabolic stress reveals widespread accumulation of cap-unmethylated RNAs

Microglia Rank signaling regulates GnRH function and the Hypothalamic-Pituitary-Gonadal axis

Single-cell profiling reveals pervasive heterogeneity in subcellular RNA localization

Unwinding of RNA G-quadruplexes induces mouse and human totipotency

A nano-liquid hub integrating growth and immune-evasion signaling to promote cell survival

A conserved mechanism of membrane fusion in nuclear pore complex assembly

A minor muscle stem cell population functions as metabolic Trojan horse fueling systemic aging by succinate induced epigenetic reprogramming

A nano-liquid hub integrating growth and immune-evasion signaling to promote cell survival

An electrostatic repulsion model of centromere organisation

Architecture and Function of Holocentric CENP-A-Independent Kinetochores

Autolamellasomes: Linking Autophagy-Dependent ER Degradation to Whorled Lysosome Biogenesis

Capturing trophectoderm-like stem cells enables step-wisely remodeling of placental development

CHPT1–LCAT rewires lipolysis towards ferroptosis

Directional branch migration remodels the meiotic Holliday junction landscape

Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis

Exosomes are specialized vehicles to induce fibronectin assembly

Ferroptosis governs lymphatic vessel growth and regression

Galvanin (TMEM154) is an electric-field sensor for directed cell migration

Genetically encoded mechano-sensors with versatile readouts and compact size

Geometric optics organizes organelle interactions and positioning

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

How the TREX-2 complex associates with the nuclear pore

Human heart organoids reveal a regenerative strategy for mitochondrial disease

Hypoxia-induced metastatic heterogeneity in pancreatic cancer

In situ Proteomics Unveils Specialized Domains for Extrasynaptic Signaling on Neuronal Cilia

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