Bioengineering

Browse the top 1% of bioengineering preprints on bioRxiv, ranked by QED Score for originality and validity. Explore new research in tissue engineering, biomaterials, drug delivery, organoids, biosensors, and medical devices, with each paper's key claims and evidence laid out clearly.

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papers in this category

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How the QED Score works

QED Score is a validated AI-based quality metric that evaluates life science papers on two dimensions: originality and validity. Each manuscript is anonymized, broken down into its claims and supporting evidence, and examined by specialized AI agents for statistical rigor, consistency across figures, and fit with the existing literature. Scores are percentile ranks, so they're comparable across fields. In blinded tests, expert professors sided with QED Score over journal rank in 75% of decisive cases.

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Physiology

Animal Behavior and Cognition

Plant Biology

Developmental Biology

Bioengineering

Lipoengineering of Biomolecular Condensates Controls Material Properties and Multiphase Hierarchy to Guide Organoid Morphogenesis

Landscape-scale navigation unlocks antibody CDR structural logic for AI-guided rescue and therapeutic optimization

Programming Biomolecular Interactions with All-Atom Generative Model

Rational design of synthetic proteins using a genome-scale CRISPR screen

Optimal hearing aid design through restoration of the neural code

Growth-adaptive spring electronics for long-term, same-neuron mapping in the developing rat brain

Programming T cells for Early Cancer Detection with Customized Protease-Activatable Receptors

MechanoMR microparticle (M3) sensors reveal dynamic stress loading as a driver of epithelial-mesenchymal transition

Programmable conjugative CRISPR interference targeting genotoxin in the gut

Mosaic pattern: lung functional heterogeneity at the alveolus level

An antifungal with a novel mechanism of action discovered via resistance gene-guided genome mining

Toward De Novo Protein Design from Natural Language

Programmable Aptamer-Embedded Circular RNAs for Targeted Antigen-Presenting Cells Immunotherapy

Chemo-mechanotherapy of fibrosis: dynamic control of biological materials through tissue-architecture-dependent crosslink disruption

Quantum Spin Resonance in Engineered Magneto-Sensitive Fluorescent Proteins Enables Multi-Modal Sensing in Living Cells

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

Megabase-scale human genome rearrangement with programmable bridge recombinases

Megabase-scale human genome rearrangement with programmable bridge recombinases

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

Quantum Spin Resonance in Engineered Magneto-Sensitive Fluorescent Proteins Enables Multi-Modal Sensing in Living Cells

Chemo-mechanotherapy of fibrosis: dynamic control of biological materials through tissue-architecture-dependent crosslink disruption

Programmable Aptamer-Embedded Circular RNAs for Targeted Antigen-Presenting Cells Immunotherapy

Toward De Novo Protein Design from Natural Language

An antifungal with a novel mechanism of action discovered via resistance gene-guided genome mining

Mosaic pattern: lung functional heterogeneity at the alveolus level

Programmable conjugative CRISPR interference targeting genotoxin in the gut

MechanoMR microparticle (M3) sensors reveal dynamic stress loading as a driver of epithelial-mesenchymal transition

Programming T cells for Early Cancer Detection with Customized Protease-Activatable Receptors

Growth-adaptive spring electronics for long-term, same-neuron mapping in the developing rat brain

Optimal hearing aid design through restoration of the neural code

Rational design of synthetic proteins using a genome-scale CRISPR screen

Programming Biomolecular Interactions with All-Atom Generative Model

Landscape-scale navigation unlocks antibody CDR structural logic for AI-guided rescue and therapeutic optimization

Lipoengineering of Biomolecular Condensates Controls Material Properties and Multiphase Hierarchy to Guide Organoid Morphogenesis

An antifungal with a novel mechanism of action discovered via resistance gene-guided genome mining

Chemo-mechanotherapy of fibrosis: dynamic control of biological materials through tissue-architecture-dependent crosslink disruption

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

Growth-adaptive spring electronics for long-term, same-neuron mapping in the developing rat brain

Landscape-scale navigation unlocks antibody CDR structural logic for AI-guided rescue and therapeutic optimization

Lipoengineering of Biomolecular Condensates Controls Material Properties and Multiphase Hierarchy to Guide Organoid Morphogenesis

MechanoMR microparticle (M3) sensors reveal dynamic stress loading as a driver of epithelial-mesenchymal transition

Megabase-scale human genome rearrangement with programmable bridge recombinases

Mosaic pattern: lung functional heterogeneity at the alveolus level

Optimal hearing aid design through restoration of the neural code

Programmable Aptamer-Embedded Circular RNAs for Targeted Antigen-Presenting Cells Immunotherapy

Programmable conjugative CRISPR interference targeting genotoxin in the gut

Programming Biomolecular Interactions with All-Atom Generative Model

Programming T cells for Early Cancer Detection with Customized Protease-Activatable Receptors

Quantum Spin Resonance in Engineered Magneto-Sensitive Fluorescent Proteins Enables Multi-Modal Sensing in Living Cells

Rational design of synthetic proteins using a genome-scale CRISPR screen

Toward De Novo Protein Design from Natural Language

How the QED Score works

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