Microbiology

Browse the top 1% of microbiology preprints on bioRxiv, ranked by QED Score for originality and validity. Explore new research on bacteria, viruses, fungi, the microbiome, antimicrobial resistance, and host-pathogen interactions, with each paper's key claims and evidence laid out clearly.

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How the QED Score works

QED Score is a validated AI-based quality metric that evaluates life science papers on two dimensions: originality and validity. Each manuscript is anonymized, broken down into its claims and supporting evidence, and examined by specialized AI agents for statistical rigor, consistency across figures, and fit with the existing literature. Scores are percentile ranks, so they're comparable across fields. In blinded tests, expert professors sided with QED Score over journal rank in 75% of decisive cases.

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Microbiology

Nucleoid-associated proteins sense phage-induced genome damage to elicit abortive infection

Immune receptor LILRB1 mediates cis-signalling which is targeted by RIFINs of the malaria parasite

Enabling the prediction of phage receptor specificity from genome data

Antiviral reverse transcriptase–primase synthesizes protein-templated DNA

Metabolic control of drug resistance by a mycobacterial ion channel

A Myb-dominated gene regulatory network universally controls sexual cell fate transitions in diatoms

RNA Quality Control Enables Antibiotic Tolerance

Core–sheath coupling controls flagellar curvature and motility in Leptospira

In situ chromatin dynamics and HIV-1 nuclear trafficking

A methylome-derived m6-dAMP trigger assembles a PUA-Cal-HAD immune filament that depletes dNTPs to abort phage infection

A dramatic protein fold switch powers a bactericidal nanomachine

Systematic discovery of TIR-based immune signaling systems in bacteria

Gut bacteria generate prodrugs in situ increasing systemic drug exposure

Early HIV-1 maturation drives Env clustering and fusion competence

Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape

Mapping unsolved lipidomes accelerates lipid discovery in major bacterial pathogens

LRP8 is a Receptor for Yellow Fever Virus

A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation

Reverse transcribed ssDNA derepresses translation of a retron antiviral protein

Epstein-Barr Virus Encoded lncRNAs Control the Viral Lytic Switch

An Anaerobic Pathogen Rewires Host Metabolism to Fuel Oxidative Growth in the Inflamed Gut

Bacterial cell wall biosynthesis is controlled by growth rate dependent modulation of turgor pressure in E. coli

Bacterial glycosphingolipids orchestrate colonization and immune modulation in neonatal host

Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance

Extracellular Vesicle-Mediated Delivery of Genetic Material for Transformation and CRISPR/Cas9-based Gene Editing in Pneumocystis murina

Temperate phages enhance host fitness via RNA-guided flagellar remodeling

A contextualised protein language model reveals the functional syntax of bacterial evolution

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry

Comprehensive architecture of the bacterial RNA interactome

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

A family of lethal exotoxins defined by cell entry via the Attractin receptor

Epstein-Barr Virus Encoded lncRNAs Control the Viral Lytic Switch

Reverse transcribed ssDNA derepresses translation of a retron antiviral protein

A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation

LRP8 is a Receptor for Yellow Fever Virus

Mapping unsolved lipidomes accelerates lipid discovery in major bacterial pathogens

Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape

Early HIV-1 maturation drives Env clustering and fusion competence

Gut bacteria generate prodrugs in situ increasing systemic drug exposure

A contextualised protein language model reveals the functional syntax of bacterial evolution

A dramatic protein fold switch powers a bactericidal nanomachine

A family of lethal exotoxins defined by cell entry via the Attractin receptor

A methylome-derived m6-dAMP trigger assembles a PUA-Cal-HAD immune filament that depletes dNTPs to abort phage infection

A Myb-dominated gene regulatory network universally controls sexual cell fate transitions in diatoms

An Anaerobic Pathogen Rewires Host Metabolism to Fuel Oxidative Growth in the Inflamed Gut

Antiviral reverse transcriptase–primase synthesizes protein-templated DNA

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry

A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation

Bacterial cell wall biosynthesis is controlled by growth rate dependent modulation of turgor pressure in E. coli

Bacterial glycosphingolipids orchestrate colonization and immune modulation in neonatal host

Comprehensive architecture of the bacterial RNA interactome

Core–sheath coupling controls flagellar curvature and motility in Leptospira

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation

Early HIV-1 maturation drives Env clustering and fusion competence

Enabling the prediction of phage receptor specificity from genome data

Epstein-Barr Virus Encoded lncRNAs Control the Viral Lytic Switch

Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance

Extracellular Vesicle-Mediated Delivery of Genetic Material for Transformation and CRISPR/Cas9-based Gene Editing in Pneumocystis murina

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

How the QED Score works

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