Systems Biology

Browse the top 1% of systems biology preprints on bioRxiv, ranked by QED Score for originality and validity. Explore new research on gene regulatory networks, signaling pathways, multi-omics integration, and computational models of biological systems, with each paper's claims and evidence laid out clearly.

15

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How the QED Score works

QED Score is a validated AI-based quality metric that evaluates life science papers on two dimensions: originality and validity. Each manuscript is anonymized, broken down into its claims and supporting evidence, and examined by specialized AI agents for statistical rigor, consistency across figures, and fit with the existing literature. Scores are percentile ranks, so they're comparable across fields. In blinded tests, expert professors sided with QED Score over journal rank in 75% of decisive cases.

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Physiology

Animal Behavior and Cognition

Plant Biology

Developmental Biology

Systems Biology

Adult regenerative defects arise from discordant scaling of signal dependent growth and patterning

X-Cell: Scaling Causal Perturbation Prediction Across Diverse Cellular Contexts via Diffusion Language Models

The Spatiotemporal Proteome Landscape of Aging: Structural determinants of age-sensitive proteome remodeling

Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neurons

Scaling perturbations: beyond genome-scale CRISPR screens

Decoding the gene regulatory landscape through multimodal learning of protein-DNA interactions

A protein language model unveils the E. coli pangenome functional landscape regulating host proteostasis

nanoPhos enables ultra-sensitive and cell-type resolved spatial phosphoproteomics

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways

Intramolecular competition generates pulsatory protein activity shaped by light, temperature, and evolution

Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome

Characterizing spatial functional microniches with SpaceTravLR

The lipidomic architecture of the mouse brain

Essentialome-Wide Multigenerational Imaging Reveals Mechanistic Origins of Cell Growth Laws

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

Essentialome-Wide Multigenerational Imaging Reveals Mechanistic Origins of Cell Growth Laws

The lipidomic architecture of the mouse brain

Characterizing spatial functional microniches with SpaceTravLR

Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome

Intramolecular competition generates pulsatory protein activity shaped by light, temperature, and evolution

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways

nanoPhos enables ultra-sensitive and cell-type resolved spatial phosphoproteomics

A protein language model unveils the E. coli pangenome functional landscape regulating host proteostasis

Decoding the gene regulatory landscape through multimodal learning of protein-DNA interactions

Scaling perturbations: beyond genome-scale CRISPR screens

Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neurons

The Spatiotemporal Proteome Landscape of Aging: Structural determinants of age-sensitive proteome remodeling

X-Cell: Scaling Causal Perturbation Prediction Across Diverse Cellular Contexts via Diffusion Language Models

Adult regenerative defects arise from discordant scaling of signal dependent growth and patterning

Adult regenerative defects arise from discordant scaling of signal dependent growth and patterning

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

A protein language model unveils the E. coli pangenome functional landscape regulating host proteostasis

Characterizing spatial functional microniches with SpaceTravLR

Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome

Decoding the gene regulatory landscape through multimodal learning of protein-DNA interactions

Essentialome-Wide Multigenerational Imaging Reveals Mechanistic Origins of Cell Growth Laws

Intramolecular competition generates pulsatory protein activity shaped by light, temperature, and evolution

nanoPhos enables ultra-sensitive and cell-type resolved spatial phosphoproteomics

Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neurons

Scaling perturbations: beyond genome-scale CRISPR screens

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways

The lipidomic architecture of the mouse brain

The Spatiotemporal Proteome Landscape of Aging: Structural determinants of age-sensitive proteome remodeling

X-Cell: Scaling Causal Perturbation Prediction Across Diverse Cellular Contexts via Diffusion Language Models

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