GEM (Growth and Evasion Metastable hub) is a ~34-nm, metastable, nano-liquid plasma membrane assembly that physically integrates receptor tyrosine kinase and CD59-mediated immune-evasion signaling through zyxin IDR2-driven liquid-liquid phase separation-like processes, enabling cooperative FAK-SFK kinase spiral activation that produces supralinear amplification of PLC γ-IP3-Ca2+ and PI3K-Akt survival signaling outputs and promotes tumor growth in vivo.

Cell survival in immune-competent organisms relies on both growth and immune evasion, yet these processes have been studied as independent cellular programs. Here, using super-resolution single-molecule imaging, we identify GEM (Growth and Evasion Metastable hub), a ≈34-nm, metastable, nano-liquid, plasma membrane hub that physically integrates receptor-type tyrosine kinase (RTK) inputs with CD59-mediated immune-evasion signaling within the same assembly. GEM is formed by LLPS-like protein clustering on PI(4,5)P2-containing raft-nanodomains. Upon concurrent RTK and CD59 stimulations, GEM recruits both receptors and downstream kinases, enabling reciprocal activation via nano-liquid confinement that supralinearly amplifies PLCγ–IP3–Ca2+ and PI3K–Akt survival signaling outputs. In mice, disrupting GEM suppresses tumor growth in vivo, establishing nano-liquid GEM as an integrator that physically couples growth and CD59-mediated immune-evasion signaling for cell survival.