Biophysics

Discover the top 1% of biophysics preprints on bioRxiv, ranked by QED Score for originality and validity. Browse new research in structural biology, cryo-EM, molecular dynamics, single-molecule methods, and protein folding, and see the claims and evidence behind each paper at a glance.

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How the QED Score works

QED Score is a validated AI-based quality metric that evaluates life science papers on two dimensions: originality and validity. Each manuscript is anonymized, broken down into its claims and supporting evidence, and examined by specialized AI agents for statistical rigor, consistency across figures, and fit with the existing literature. Scores are percentile ranks, so they're comparable across fields. In blinded tests, expert professors sided with QED Score over journal rank in 75% of decisive cases.

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Biophysics

Twist-Dependent Elastic Limits and Unwinding of Tightly Bent DNA

The cytoplasmic lattice in mammalian eggs sequesters ubiquitination machinery and tubulin in reserve

Positional information and information flows in dynamic tissues

Force-modulated structural landscape of the catch bonding F-actin crosslinker α-actinin-4

Biophysical fitness landscape design traps viral evolution

IR-AMES uncovers structure and composition of Alzheimer’s tau oligomers

Chromatin boundary permeability is controlled by CTCF conformational ensembles

Bacterial GTPases act as successive placeholders to mediate ribosome assembly and its coupling to translation initiation

A universal scaling law for mitotic spindles across eukaryotes driven by chromosome crowding

Ubiquitous low-energy RNA fluctuations and energetic coupling measured by chemical probing

Super-resolved imaging of mRNA ultrastructure in cells

Single-molecule dissection of CFTR folding defects and pharmacological rescue

Long-term single-molecule Ca2+ flux recordings reveal mode-switching regulation of Ca2+-ATPases

Synaptic active zones are ordered nanostructures designed by supramolecular block copolymers

O-GlcNAcylation and an importin-β radial gradient keep the FG barrier liquid in live-cell nuclear pores

Amyloid-mediated RNA uptake by sperm for embryonic delivery

Adaptor protein supersaturation drives innate immune signaling and cell fate

A complete map of specificity encoding enables reprogramming of a dynamic protein interaction

Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation

De novo design of light-regulated dynamic proteins using deep learning

Condenzymes: Biomolecular condensates with inherent catalytic activities

Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia

Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins

An artificial motor protein that walks along a DNA track

Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gating

Single-cell imaging reveals spontaneous phenotypic sorting and bet-hedging in developing biofilms

Structures of protein folding intermediates on the ribosome

The structural basis of cold sensitivity

Emergence of specific binding and catalysis from a designed generalist binding protein

Systematic DNA nicking reveals the structural logic of protein recognition

A protein-DNA surface hydrogel mechanically reinforces the cell nucleus and protects the genome

Deep learning-based joint sequence–structure de novo membrane protein design

Molecular characterization of an adhesion GPCR signal transduction

Tissue surface mechanics constrains proliferation-driven forces to guide mammalian body axis elongation

De novo design of light-regulated dynamic proteins using deep learning

Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation

A complete map of specificity encoding enables reprogramming of a dynamic protein interaction

Adaptor protein supersaturation drives innate immune signaling and cell fate

Amyloid-mediated RNA uptake by sperm for embryonic delivery

O-GlcNAcylation and an importin-β radial gradient keep the FG barrier liquid in live-cell nuclear pores

A complete map of specificity encoding enables reprogramming of a dynamic protein interaction

Adaptor protein supersaturation drives innate immune signaling and cell fate

Amyloid-mediated RNA uptake by sperm for embryonic delivery

An artificial motor protein that walks along a DNA track

A protein-DNA surface hydrogel mechanically reinforces the cell nucleus and protects the genome

A universal scaling law for mitotic spindles across eukaryotes driven by chromosome crowding

Bacterial GTPases act as successive placeholders to mediate ribosome assembly and its coupling to translation initiation

Biophysical fitness landscape design traps viral evolution

Chromatin boundary permeability is controlled by CTCF conformational ensembles

Condenzymes: Biomolecular condensates with inherent catalytic activities

Deep learning-based joint sequence–structure de novo membrane protein design

De novo design of light-regulated dynamic proteins using deep learning

Emergence of specific binding and catalysis from a designed generalist binding protein

Force-modulated structural landscape of the catch bonding F-actin crosslinker α-actinin-4

IR-AMES uncovers structure and composition of Alzheimer’s tau oligomers

Long-term single-molecule Ca2+ flux recordings reveal mode-switching regulation of Ca2+-ATPases

Molecular characterization of an adhesion GPCR signal transduction

Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation

Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia

O-GlcNAcylation and an importin-β radial gradient keep the FG barrier liquid in live-cell nuclear pores

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