Neuroscience

Explore the top 1% of neuroscience preprints on bioRxiv, ranked by QED Score for originality and validity. This collection covers new research on neural circuits, synaptic plasticity, neurodegeneration, cognition, and brain development, with each paper broken down into its key claims and evidence so you can find the strongest new findings before they reach journals.

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How the QED Score works

QED Score is a validated AI-based quality metric that evaluates life science papers on two dimensions: originality and validity. Each manuscript is anonymized, broken down into its claims and supporting evidence, and examined by specialized AI agents for statistical rigor, consistency across figures, and fit with the existing literature. Scores are percentile ranks, so they're comparable across fields. In blinded tests, expert professors sided with QED Score over journal rank in 75% of decisive cases.

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Neuroscience

Memory erasure by dopamine-gated retrospective learning

Hierarchical processing and polarization encoding in the cephalopod visual system

Dual Engram Architecture within a Single Striatal Cell Type Distinctly Controls Alcohol Relapse and Extinction

Connectome of a human foveal retina

Comprehensive profiling of anaesthetised brain dynamics across phylogeny

The organization of visual pathways in the Drosophila brain

Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology

Octopamine instructs head direction plasticity

Neocortical long-range inhibition promotes cortical synchrony and sleep

Multimodal spatial transcriptomics determines repeat expansion, huntingtin aggregation, and selective cortical neuron loss in Huntington’s Disease

Emergence of Functional Heart-Brain Circuits in a Vertebrate

Dose-dependent NFI regulation of progenitor lifespan and output underlying human neocortical malformation

Cross-species consensus atlas of the primate basal ganglia

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses

Circuit-specific gene editing for precision modulation of neuronal activity with CRISPR-rabies virus

A lateralized pathway for associating nutrients with flavors

A dividing cell model for stable propagation and curing of bona fide human sporadic Creutzfeldt-Jakob Disease prions

Sexual dimorphism in the complete connectome of the Drosophila male central nervous system

Neuronal activity triggers widespread changes in RNA stability

Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain

A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain

Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilization

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia

Nuclear Receptor Transcription Factors promote axon regeneration in the Adult Corticospinal Tract

Single Cell Proteomics in the Developing Human Brain

Spatial coupling of endogenous Tau translation and degradation by neuroproteasomes in dendrites revealed by STARFISH

Two Specialized Intrinsic Cardiac Neuron Types Safeguard Heart Homeostasis and Stress Resilience

AI Discovery of Mechanisms of Consciousness, Its Disorders, and Their Treatment

Synaptic sign switching mediates online dopamine updates

Ultra-high-field fMRI reveals layer-specific responses in the human spinal cord

A molecular and spinal circuit basis for the functional segregation of itch and pain

Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits

Interpretable Machine Learning Identifies an Emergent Absence Seizure Mechanism

Motor cortex flexibly deploys a high-dimensional repertoire of subskills

A hardwired neural circuit for temporal difference learning

A shared code for perceiving and imagining objects in human ventral temporal cortex

Coding for Circuit Integration in the Injured Brain by Transplanted Human Neurons

Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB

A Brainwide Atlas of Synaptic Nanoarchitecture Across the Mouse Lifespan

A Community Standard Multispecies Cell Atlas of the Basal Ganglia

A Developmental Atlas of the Drosophila Nerve Cord Uncovers a Global Temporal Code for Neuronal Identity

A dividing cell model for stable propagation and curing of bona fide human sporadic Creutzfeldt-Jakob Disease prions

A genetically defined injured C-fibre nociceptor associated with neuromas drives chronic spontaneous neuropathic pain

A hardwired neural circuit for temporal difference learning

AI Discovery of Mechanisms of Consciousness, Its Disorders, and Their Treatment

A lateralized pathway for associating nutrients with flavors

A molecular and spinal circuit basis for the functional segregation of itch and pain

A multiplexed striatal architecture for generalized spatial goal progress

A neuron-glia circuit anticipates hypoxia to regulate organismal oxygen use

A right-hemispheric language network at single-neuron resolution

A shared code for perceiving and imagining objects in human ventral temporal cortex

A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain

Astrocyte-induced internal state transitions reshape brainwide sensory, integrative, and motor computations

A walk-sum framework of frequency-dependent brain communication architecture

Cell type-specific barcoding reveals the single-neuron projectional architecture of the mouse midbrain dopaminergic system

Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease

Cellular coding of ingestion in the caudal brainstem

Circuit-specific gene editing for precision modulation of neuronal activity with CRISPR-rabies virus

How the QED Score works

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