Cancer Biology

Explore the top 1% of cancer biology preprints on bioRxiv, ranked by QED Score for originality and validity. This collection covers new research on tumor biology, oncogenes, the tumor microenvironment, metastasis, cancer immunotherapy, and drug resistance, with a claim-by-claim breakdown of each paper's evidence.

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papers in this category

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How the QED Score works

QED Score is a validated AI-based quality metric that evaluates life science papers on two dimensions: originality and validity. Each manuscript is anonymized, broken down into its claims and supporting evidence, and examined by specialized AI agents for statistical rigor, consistency across figures, and fit with the existing literature. Scores are percentile ranks, so they're comparable across fields. In blinded tests, expert professors sided with QED Score over journal rank in 75% of decisive cases.

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Physiology

Animal Behavior and Cognition

Plant Biology

Developmental Biology

Cancer Biology

De novo H3.3K27M-altered Diffuse Midline Glioma in human brainstem organoids to dissect GD2 CAR T cell function

A gastric microbial chromatin remodeler drives gastric cancer progression and immune evasion by reprogramming the host epigenome

eIF2B Selectively Anchors and Activates Mutant KRAS

Mitochondria redistribution organizes the immunosuppressive tumor ecosystem

Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumour growth and metastasis

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation

Leveraging WNT Hyperactivation to Kill Colorectal Cancer While Rejuvenating Healthy Intestine

Genetic elements promote retention of extrachromosomal DNA in cancer cells

Functional interrogation uncovers a critical role for a high-plasticity cell state in lung adenocarcinoma

Tumor Genotype Dictates Mitochondrial and Immune Vulnerabilities in Liver Cancer

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis

Mechanoimmunological Control of Metastatic Site Selection

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics

Mechanoimmunological Control of Metastatic Site Selection

Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

Tumor Genotype Dictates Mitochondrial and Immune Vulnerabilities in Liver Cancer

Functional interrogation uncovers a critical role for a high-plasticity cell state in lung adenocarcinoma

Genetic elements promote retention of extrachromosomal DNA in cancer cells

Leveraging WNT Hyperactivation to Kill Colorectal Cancer While Rejuvenating Healthy Intestine

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation

Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumour growth and metastasis

Mitochondria redistribution organizes the immunosuppressive tumor ecosystem

eIF2B Selectively Anchors and Activates Mutant KRAS

A gastric microbial chromatin remodeler drives gastric cancer progression and immune evasion by reprogramming the host epigenome

De novo H3.3K27M-altered Diffuse Midline Glioma in human brainstem organoids to dissect GD2 CAR T cell function

The subclonal footprint of pervasive early dissemination in pancreatic cancer

Critical role of cell competition in gliomagenesis

Genotype-phenotype mapping identifies fetal-like CD55+ immunoregulatory cancer cells as mediators of immune escape in colorectal cancer

Glucokinase links metabolism and lineage plasticity in neuroendocrine prostate cancer via interaction with AKT1

A gastric microbial chromatin remodeler drives gastric cancer progression and immune evasion by reprogramming the host epigenome

An Endocytic Checkpoint Controls Macrophage PD-1 Function and Immunotherapy Fate

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

A targetable dependency on nonsense-mediated decay for proteostasis and immune control in small cell lung cancer

Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination

Critical role of cell competition in gliomagenesis

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics

De novo H3.3K27M-altered Diffuse Midline Glioma in human brainstem organoids to dissect GD2 CAR T cell function

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

Dynamic optimization of extrachromosomal DNA copy number drives tumour evolution

eIF2B Selectively Anchors and Activates Mutant KRAS

Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survival

Fatty acid scavenging enables cancer escape from KRAS inhibition

Functional interrogation uncovers a critical role for a high-plasticity cell state in lung adenocarcinoma

Genetic elements promote retention of extrachromosomal DNA in cancer cells

Genotype-phenotype mapping identifies fetal-like CD55+ immunoregulatory cancer cells as mediators of immune escape in colorectal cancer

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

Glucokinase links metabolism and lineage plasticity in neuroendocrine prostate cancer via interaction with AKT1

Inflammatory memory disables a DDR1 degradation checkpoint to enable pancreatic cancer growth

Leveraging WNT Hyperactivation to Kill Colorectal Cancer While Rejuvenating Healthy Intestine

How the QED Score works

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