Developmental Biology

Explore the top 1% of developmental biology preprints on bioRxiv, ranked by QED Score for originality and validity. This collection features new research on embryonic development, stem cells, organogenesis, tissue patterning, and regeneration, with a breakdown of each paper's claims and supporting evidence.

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How the QED Score works

QED Score is a validated AI-based quality metric that evaluates life science papers on two dimensions: originality and validity. Each manuscript is anonymized, broken down into its claims and supporting evidence, and examined by specialized AI agents for statistical rigor, consistency across figures, and fit with the existing literature. Scores are percentile ranks, so they're comparable across fields. In blinded tests, expert professors sided with QED Score over journal rank in 75% of decisive cases.

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Physiology

Animal Behavior and Cognition

Plant Biology

Developmental Biology

Developmental Biology

Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate

Genetic mosaics reveal mechanisms of resistance to VEGF signaling loss during angiogenesis

Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases

A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics

Reconstitution of adrenocortical functional zonation from human pluripotent stem cells

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates

An embryonic artery-forming niche reactivates in pulmonary arterial hypertension

An embryonic artery-forming niche reactivates in pulmonary arterial hypertension

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates

Reconstitution of adrenocortical functional zonation from human pluripotent stem cells

A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics

Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases

Genetic mosaics reveal mechanisms of resistance to VEGF signaling loss during angiogenesis

Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate

Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning

Piezo1–Yap1 signalling translates tissue mechanics into regenerative cell states

Separately prestored proteasome components to prevent polyspermy

A conserved logic for the development of cortical layering in tetrapods

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding

Induction of menstruation in mice reveals the regulation of menstrual shedding

Mechanical control of histone serotonylation initiates neural crest migration in vivo

A stem cell knockout village reveals lineage rewiring and a non-canonical islet cell fate in monogenic diabetes

Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data

Human trunk embryoids with patterned anterior-posterior and dorsal-ventral body axes: utility for understanding human development and disease

Buckling instability underlies vertebral segmentation during axolotl tail regeneration

Lamin A/C directs nucleosome-scale chromatin remodeling to define early lineage segregation in mammals

Early development of male germ cell clones shapes their reproductive success

A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics

A conserved logic for the development of cortical layering in tetrapods

A mitochondrial program encodes brain vascular reserve

An embryonic artery-forming niche reactivates in pulmonary arterial hypertension

An integrated single cell and spatial omics atlas of human prenatal development

A stem cell knockout village reveals lineage rewiring and a non-canonical islet cell fate in monogenic diabetes

A tunnel microtract organ for T cell progenitor homing is formed by neural crest morphogenesis via Sox10-Cdc42 axis

Buckling instability underlies vertebral segmentation during axolotl tail regeneration

Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate

Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning

Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data

Early development of male germ cell clones shapes their reproductive success

Genetic mosaics reveal mechanisms of resistance to VEGF signaling loss during angiogenesis

Hierarchical Assembly of Native Cytoplasmic Lattices Revealed by Cryo-EM

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding

Human trunk embryoids with patterned anterior-posterior and dorsal-ventral body axes: utility for understanding human development and disease

Induction of menstruation in mice reveals the regulation of menstrual shedding

Lamin A/C directs nucleosome-scale chromatin remodeling to define early lineage segregation in mammals

Mechanical control of histone serotonylation initiates neural crest migration in vivo

Mitotic bookmarking by Prox1 preserves mammalian neuronal lineage identity memory via promoting timely H3K27me3 restoration

How the QED Score works

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