Immunology

Browse the top 1% of immunology preprints on bioRxiv, ranked by QED Score for originality and validity. Explore new research on innate and adaptive immunity, T cell and B cell biology, inflammation, autoimmunity, and vaccines, with each paper's claims and supporting evidence laid out clearly.

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How the QED Score works

QED Score is a validated AI-based quality metric that evaluates life science papers on two dimensions: originality and validity. Each manuscript is anonymized, broken down into its claims and supporting evidence, and examined by specialized AI agents for statistical rigor, consistency across figures, and fit with the existing literature. Scores are percentile ranks, so they're comparable across fields. In blinded tests, expert professors sided with QED Score over journal rank in 75% of decisive cases.

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Immunology

Structural insights into antibody responses against influenza A virus in its natural reservoir

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

IL-17RC signaling connects intestinal microbiota and neuroimmune interactions in atherosclerosis

Hidden immune memory niches in inflammatory skin diseases

DNA-triggered AIM2 condensation orchestrates immune activation and regulation

Atomistic TCR-ligand interactions shape memory T-cell differentiation

A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging

immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse

The ontogeny of myeloid-stromal synovial tissue niches in rheumatoid arthritis

Myeloid CD209 impairs T-cell activation by inducing ICAM-2–ERM–dependent cortical stiffening

Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential

Awakening intracellular immunity for functional HIV cure

Tyrosine halogenation converts α-defensins into potent immunomodulators

Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate

IGHV3-53 antibody abundance drives divergent SARS-CoV-2 immune imprinting

Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responses

AI recognizes convergent somatic hypermutation signatures to allow the discovery of variant-resilient broadly neutralizing antibodies

Lymphatic constraint of germinal centers optimizes protective antibody responses

GM-CSF instructs vertebral emergency myelopoiesis in neuropathic pain

Cancers modulate p53 truncal neoantigen display to evade T cell detection

Lymphatic constraint of germinal centers optimizes protective antibody responses

AI recognizes convergent somatic hypermutation signatures to allow the discovery of variant-resilient broadly neutralizing antibodies

Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responses

IGHV3-53 antibody abundance drives divergent SARS-CoV-2 immune imprinting

Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate

Tyrosine halogenation converts α-defensins into potent immunomodulators

Awakening intracellular immunity for functional HIV cure

Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential

Myeloid CD209 impairs T-cell activation by inducing ICAM-2–ERM–dependent cortical stiffening

The ontogeny of myeloid-stromal synovial tissue niches in rheumatoid arthritis

immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse

A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging

Atomistic TCR-ligand interactions shape memory T-cell differentiation

DNA-triggered AIM2 condensation orchestrates immune activation and regulation

Hidden immune memory niches in inflammatory skin diseases

IL-17RC signaling connects intestinal microbiota and neuroimmune interactions in atherosclerosis

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

Structural insights into antibody responses against influenza A virus in its natural reservoir

IL-17RC signaling connects intestinal microbiota and neuroimmune interactions in atherosclerosis

immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse

In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors

Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential

Lymphatic constraint of germinal centers optimizes protective antibody responses

Memory Regulatory T Cells Reprogram into Protective Tfh-like Effectors in Recurrent Malaria

Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility

Myeloid CD209 impairs T-cell activation by inducing ICAM-2–ERM–dependent cortical stiffening

P2RY2 is a purinergic immune checkpoint linking extracellular ATP to immune evasion and adaptive resistance to immunotherapy

Replaying germinal center evolution on a quantified affinity landscape

RNA splicing dynamics in CD8 T cells uncovers isoforms that impact T cell-mediated cancer immunotherapy

Sideways lipid presentation by the antigen-presenting molecule CD1c

Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate

Structural insights into antibody responses against influenza A virus in its natural reservoir

Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery

T cell ectosomes promote antibody responses through cognate TCR-pMHC interactions

The ontogeny of myeloid-stromal synovial tissue niches in rheumatoid arthritis

Tyrosine halogenation converts α-defensins into potent immunomodulators

How the QED Score works

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