Synthetic Biology

Discover the top 1% of synthetic biology preprints on bioRxiv, ranked by QED Score for originality and validity. Browse new research on genetic circuits, metabolic engineering, protein design, gene editing tools, and engineered cells, and see the claims and evidence behind each paper at a glance.

21

papers in this category

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How the QED Score works

QED Score is a validated AI-based quality metric that evaluates life science papers on two dimensions: originality and validity. Each manuscript is anonymized, broken down into its claims and supporting evidence, and examined by specialized AI agents for statistical rigor, consistency across figures, and fit with the existing literature. Scores are percentile ranks, so they're comparable across fields. In blinded tests, expert professors sided with QED Score over journal rank in 75% of decisive cases.

Read the methodology

Physiology

Animal Behavior and Cognition

Plant Biology

Developmental Biology

Synthetic Biology

De novo design of hundreds of functional GPCR-targeting antibodies enabled by scaling test-time compute

Expanding the genetic code with diverse backbone structures across diverse sequence contexts

A cinnamyl alcohol dehydrogenase scaffold organizes monoterpenoid indole alkaloid biosynthesis

A portable orthogonal replication system enables continuous gene evolution near the biological speed limit

A Scalable Design for Proximity-Inducing Molecules

Bridge recombinase enables versatile rewriting of bacterial genomes

De novo design of hundreds of functional GPCR-targeting antibodies enabled by scaling test-time compute

De novo design of metalloproteases for targeted amyloid-β cleavage

De novo design of metal-oxide templating proteins

Engineering Cybergenetic Cell-Based Therapies

Escherichia coli with a 57-codon genetic code

Expanding the genetic code with diverse backbone structures across diverse sequence contexts

Generative design of novel bacteriophages with genome language models

Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling

Harnessing transcription factor activity for programmable therapeutic gene regulation

Human Genome REWRITE for Off-the-Shelf Stem Cells Reveals an “Epigenetic Ghost”

Light-directed evolution of dynamic, multi-state, and computational protein functionalities

Microdroplet screening rapidly profiles a biocatalyst to enable its AI-assisted engineering

Multiplex design and discovery of proximity handles for programmable proteome editing

Programming human cell type-specific gene expression via an atlas of AI-designed enhancers

Reprogrammed Serine Integrases Enable Precise Integration of Synthetic DNA

Statistical design of a synthetic microbiome that suppresses diverse gut pathogens

How the QED Score works

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